Sulfadiazine sodium bụ ọgwụ nje sulfonamide na-arụ ọrụ nke na-enwe mmetụta antibacterial na ọtụtụ nje gram-positive na gram-adịghị mma. Ọ nwere mmetụta antibacterial na Staphylococcus aureus na-abụghị enzyme, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, Neisseria gonorrhoeae, Neisseria meningitidis, na Haemophilus influ. Na mgbakwunye, ọ na-arụkwa ọrụ megide Chlamydia trachomatis, Nocardia asteroides, Plasmodium, na Toxoplasma in vitro. Ọrụ antibacterial nke ngwaahịa a bụ otu nke sulfamethoxazole. Otú ọ dị, n'ime afọ ndị na-adịbeghị anya, nje na-eguzogide ngwaahịa a abawanyela, karịsịa Streptococcus, Neisseria, na Enterobacteriaceae.